Ken

Principle investigator Associate Professor

[New Publication] Primed human pluripotent stem cell-derived blastocyst-like cell aggregates with partial lineage specification

Our latest paper, “Primed human pluripotent stem cell-derived blastocyst-like cell aggregates with partial lineage specification,” has been published in Regenerative Therapy (Elsevier, 2025) — DOI: 10.1016/j.reth.2025.10.007. We report a hydrogel-based method to generate blastocyst-like structures directly from primed human pluripotent stem cells, without the need for naïve reprogramming.These aggregates mimic Read more…

By Ken, ago

[New Publication] High-Purity Production of Endothelial Cells from Human Pluripotent Stem Cells

Authors: Koki Yoshimoto, Ririka Okaichi, Kei Iida, Shiho Terada, and Ken-ichiro Kamei Our latest paper, “High-Purity Production of Endothelial Cells from Human Pluripotent Stem Cells”, has been published in Cell Therapy & Engineering Connect. We report a simple, sorting-free method to produce over 90% pure endothelial cells from human pluripotent Read more…

By Ken, ago

[New Publication] Tumor-on-a-Chip Guided NSCLC Nanotherapy

Our latest research has been published in Chemical Engineering Journal: Title: Nanoengineered Redox-Responsive Platforms for Dual-Targeted NSCLC Therapy with Tumor-on-a-Chip Epithelial-Mesenchymal Transition Profiling In this work, we present a rationally designed binary hybrid nanoassembly (OL@R NPs) that co-delivers a redox-responsive platinum(IV) prodrug of oxaliplatin and the ferroptosis inducer RSL3. This Read more…

By Ken, ago

[New Publication] Self-Boosting Nanoparticles to Enhance Cancer Therapy

Thrilled to share our latest work in collaboration with Shenyang Pharmaceutical University, now published in the International Journal of Pharmaceutics: Title:Self-amplifying ROS-responsive trinity nanodelivery system for enhanced cancer therapy Highlights: 🧪 This study showcases the power of integrating nanotechnology with advanced in vitro and in vivo models to address ferroptosis Read more…

By Ken, ago

[New publication] Nano-drug delivery for photodynamic therapy in Nano Research!

We are thrilled to share our latest research in collaboration with Shenyang Pharmaceutical University! Our study, led by Dr. Chutong Tian, introduces a self-motivated carrier-free nanoplatform that synergizes photodynamic therapy (PDT) and ferroptosis for targeted anticancer treatment. Title: A self-motivated carrier free nanoplatform for synergistic photodynamic and ferroptosis-based therapy for Read more…

By Ken, ago

[New Publication (Review)] Peptide-based fluorescent Probes for cancer diagnosis and surgery, published in Biosensors & Bioelectronics!

I’m thrilled to share our latest review article, published in Biosensors & Bioelectronics, on the advancements of peptide-based fluorescent probes for tumor imaging. This work is the result of a wonderful collaboration with Prof. Hao Wang at the CAS Center for Excellence in Nanoscience, China. Fluorescent contrast agents are essential Read more…

By Ken, ago

[New publication] Nanodiamonds as a temperature sensor, published in Sensors & Actuators A: Physical

We are excited to share our latest research published in Sensors & Actuators A: Physical! Title: Microfluidics-guided fluorescent nanodiamond assembly method for highly sensitive thermometry Authors: Keita Saikawa, Masaya Zetsu, Daiki Ueshima, Taiichi Shikama, Ken-ichiro Kamei, Osamu Tabata, Yoshikazu Hirai In this study, we tackled a key challenge in fluorescent nanodiamond (FND)-based thermometry—enhancing sensitivity for practical applications. FNDs with nitrogen vacancy centers (NVCs) Read more…

By Ken, ago

[New publication] Nanodrug delivery system in Carbon!

Exciting News! Our latest work in Carbon presents a stimulus-responsive, carrier-free prodrug nano-delivery system for enhanced cancer therapy. By designing ROS-responsive SN38-CA@FC nanoparticles, we achieve a synergistic effect of chemotherapy and ferroptosis, leveraging tumor-specific smart drug release. This approach not only enhances SN38’s therapeutic efficacy but also disrupts redox homeostasis, Read more…

By Ken, ago
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