[New Publication] Primed human pluripotent stem cell-derived blastocyst-like cell aggregates with partial lineage specification

Our latest paper, “Primed human pluripotent stem cell-derived blastocyst-like cell aggregates with partial lineage specification,” has been published in Regenerative Therapy (Elsevier, 2025) — DOI: 10.1016/j.reth.2025.10.007. We report a hydrogel-based method to generate blastocyst-like structures directly from primed human pluripotent stem cells, without the need for naïve reprogramming.These aggregates mimic Read more…

[New Publication] Tumor-on-a-Chip Guided NSCLC Nanotherapy

Our latest research has been published in Chemical Engineering Journal: Title: Nanoengineered Redox-Responsive Platforms for Dual-Targeted NSCLC Therapy with Tumor-on-a-Chip Epithelial-Mesenchymal Transition Profiling In this work, we present a rationally designed binary hybrid nanoassembly (OL@R NPs) that co-delivers a redox-responsive platinum(IV) prodrug of oxaliplatin and the ferroptosis inducer RSL3. This Read more…

[New publication] Nano-drug delivery for photodynamic therapy in Nano Research!

We are thrilled to share our latest research in collaboration with Shenyang Pharmaceutical University! Our study, led by Dr. Chutong Tian, introduces a self-motivated carrier-free nanoplatform that synergizes photodynamic therapy (PDT) and ferroptosis for targeted anticancer treatment. Title: A self-motivated carrier free nanoplatform for synergistic photodynamic and ferroptosis-based therapy for Read more…

[New publication] Nanodrug delivery system in Carbon!

Exciting News! Our latest work in Carbon presents a stimulus-responsive, carrier-free prodrug nano-delivery system for enhanced cancer therapy. By designing ROS-responsive SN38-CA@FC nanoparticles, we achieve a synergistic effect of chemotherapy and ferroptosis, leveraging tumor-specific smart drug release. This approach not only enhances SN38’s therapeutic efficacy but also disrupts redox homeostasis, Read more…

[New publication] Journal of Micromechanics and Microengineering!

Title: Evaluation of solvent releases from microfluidic devices made of cyclo orefin polymer by temperature-desorption mass spectrometry Authors: S. Takahashi, Y. Mune, A. Yamamuro, A. Aiba, K. Hatakeyama, K. Kamei DOI: 10.1088/1361-6439/accd00 Abstract: Microfluidic devices have been used in various biological experiments. The working temperature of the devices spans a Read more…

[New publication] Communications Biology!

Our collaborative research (Dr. Hirai, Dr. Yang, Dr. Iida, and Prof. Tabata) got published in Communications Biology! Organs-on-a-Chip for in vitro model of non-alcoholic fatty liver disease/ Title: Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease Authors: Jiandong Yang, Yoshikazu Hirai, Kei Iida, Shinji Ito, Marika Trumm, Shiho Terada, Risako Sakai, Toshiyuki Read more…

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