Ideas, devices, and materials
Patents
Engineering gives us new ways to study living systems. Explore inventions involving organ-on-a-chip platforms, stem-cell culture, and the materials and measurements that make these systems possible.
Bibliographic review: · Grouped by invention and earliest priority year
2021–2020
Organ models, circulation, and physical control of cells.
Grant document(s) available
Circulating culture medium in cell-culture plates
A circulation system that moves nutrient medium between culture wells in a closed loop.
Patent details: Circulating culture medium in cell-culture plates
- Document title
- Culture medium circulation device
- Inventors
- T. Sato; H. Nakamoto; H. Inoue; M. Takashima; K. Kamei; S. Imamura; A. Kikkawa
- Named applicants
- AquaTech Co., Ltd.; Kyoto University
- Application number(s)
- Japan: 2021-171186
- Earliest priority
- Japanese filing
- Japan registration
- Publication dates
- JP7565033B2:
- Original document
- Read the published patent PDF ↗
Grant document(s) available
Multilayer organ-on-a-chip systems
Layered microfluidic environments for growing structured neural organoids and studying aspects of neurological disease.
Patent details: Multilayer organ-on-a-chip systems
- Document title
- Multilayered organ-on-a-chip systems and methods of use thereof
- Inventors
- Momoko Watanabe; Kenichiro Kamei
- Named applicants
- The Regents of the University of California
- Application number(s)
- United States: 17/670,404; related provisional application: 63/149,213
- Earliest priority
- US non-provisional filing
- Publication dates
- US12054698B2:
- Original document
- Read the published patent PDF ↗
The provisional application was filed on 2021-02-12. The US patent was granted on 2024-08-06; this is not the non-provisional filing date. The applicant is taken from the patent cover.
Published application
Modelling the forces of eye blinking on a chip
A membrane-based culture system with controlled fluid flow to reproduce shear forces acting on corneal cells.
Patent details: Modelling the forces of eye blinking on a chip
- Document title
- Microfluidic device, cell culture system, and cell culture method
- Inventors
- Kenichiro Kamei; R. Abdalkader
- Named applicants
- Kyoto University
- Application number(s)
- Japan: 2020-190869
- Earliest priority
- Japanese filing
- Publication dates
- JP2022079964A:
- Original document
- Read the published patent PDF ↗
Published application
Controlling gene expression with terahertz pulses
An apparatus for applying carefully controlled terahertz-wave pulses to living cells while maintaining their culture environment.
Patent details: Controlling gene expression with terahertz pulses
- Document title
- Gene expression control device and gene expression control method
- Inventors
- Takehiro Tachizaki; Hideki Hirori; Kenichiro Kamei; Reiko Sakaguchi
- Named applicants
- Tokai University
- Application number(s)
- Japan: 2020-143603
- Earliest priority
- Japanese filing
- Publication dates
- JP2022038894A:
- Original document
- Read the published patent PDF ↗
This public application is also listed in Kyoto University's faculty research record.
2019–2018
Culture-chip design and measurements of cell barriers.
Grant document(s) available
Measuring cell-barrier function on a chip
A microfluidic device with electrodes arranged to measure the electrical resistance of a cell layer—a way to monitor how well it forms a barrier.
Patent details: Measuring cell-barrier function on a chip
- Document title
- microfluidic device
- Inventors
- K. Kamei; Y. Hirai; O. Tabata; T. Miyazaki
- Named applicants
- Kyoto University
- Application number(s)
- Japan: 2019-048928
- Earliest priority
- Japanese filing
- Publication dates
- JP7217521B2:
- Original document
- Read the published patent PDF ↗
Grant document(s) available
Culture vessels with electrical readouts
A culture vessel that combines membrane-grown cells with electrode chambers for measuring electrical resistance.
Patent details: Culture vessels with electrical readouts
- Document title
- cell culture vessel
- Inventors
- K. Fukue; K. Kamei; Y. Hirai; O. Tabata
- Named applicants
- SCREEN Holdings Co., Ltd.; Kyoto University
- Application number(s)
- Japan: 2018-238405
- Earliest priority
- Japanese filing
- Publication dates
- JP7107528B2:
- Original document
- Read the published patent PDF ↗
Inventors are listed as recorded in the published patent document. A historical grant publication does not establish that patent rights remain in force.
Published application
Small, controlled three-dimensional culture spaces
A culture chip with a narrow, non-porous chamber designed to recreate aspects of the environment around cells.
Patent details: Small, controlled three-dimensional culture spaces
- Document title
- Cell culturing chip
- Inventors
- M. Yamanaka; K. Kamei
- Named applicants
- Ushio Inc.; Kyoto University
- Application number(s)
- PCT/JP2019/043128; Japanese priority application: 2018-210066
- Earliest priority
- International filing
- Publication dates
- WO2020095852A1:
- Original document
- Read the published patent PDF ↗
Grant document(s) available
Manufacturing cell-culture chips
Chip structures and production methods that combine transparent culture chambers with surfaces designed to control wetting.
Patent details: Manufacturing cell-culture chips
- Document title
- CELL CULTURE CHIP AND MANUFACTURING METHOD THEREOF
- Inventors
- M. Yamanaka; K. Kamei
- Named applicants
- Ushio Inc.; Kyoto University
- Application number(s)
- Japan: 2018-210069; PCT/JP2019/043109
- Earliest priority
- Japanese priority filing
- Publication dates
- JP7246041B2:
WO2020095849A1: - Original document
- Read the published patent PDF ↗
The international application was filed on 2019-11-01. Applicant names refer to the published records, not a certification of current ownership.
2014–2012
Three-dimensional culture, stem-cell induction, and engineered scaffolds.
Published application
Guiding stem cells toward liver and pancreatic lineages
Culture methods and induction tools for producing endodermal cells and cells of liver or pancreatic lineages from pluripotent stem cells.
Patent details: Guiding stem cells toward liver and pancreatic lineages
- Document title
- Endodermal cell production method, liver cell production method, pancreatic cell production method, endodermal cell induction promoter, liver cell induction promoting kit, pancreatic cell induction promoting kit, and micro fluid device
- Inventors
- Kenichiro Kamei; Momoko Honda (本田 桃子, as recorded in the publication)
- Named applicants
- Kyoto University
- Application number(s)
- PCT/JP2015/085894
- Earliest priority
- International filing
- Publication dates
- WO2016104541A1:
- Original document
- Read the published patent PDF ↗
Grant document(s) available
Biodegradable scaffolds for three-dimensional cell culture
A biodegradable support coated with fine polymer fibres for growing cells in three dimensions and investigating cell-transplantation approaches.
Patent details: Biodegradable scaffolds for three-dimensional cell culture
- Document title
- Three-dimensional culture method using biodegradable polymer and culture substrate enabling cell transplantation
- Inventors
- K. Kamei; L. Liu; N. Nakatsuji; Y. Chen; H. Sato; M. Suzuki
- Named applicants
- Gunze Limited; Kyoto University
- Application number(s)
- PCT/JP2015/080641; Japanese national application: 2016-556642
- Earliest priority
- International filing
- Publication dates
- JP6758625B2:
WO2016068266A1: - Original document
- Read the published patent PDF ↗
Grant document(s) available
Three-dimensional cell culture with chemical gradients
Microfluidic chambers that expose hydrogel-grown cells to controlled concentration gradients of biological signals.
Patent details: Three-dimensional cell culture with chemical gradients
- Document title
- Microfluid device and three-dimensional microculture method for cell
- Inventors
- Kenichiro Kamei; Yong Chen
- Named applicants
- Kyoto University (international and Japanese publications); Kyoto University and Ushio Inc. (US grant)
- Application number(s)
- PCT/JP2015/055178; US: 15/121,553; Japan: 2016-505223
- Earliest priority
- International filing
- Publication dates
- US11130935B2:
JP6486898B2:
WO2015129673A1: - Original document
- Read the published patent PDF ↗
Grant document(s) available
Functional polymer fibres for cell-culture scaffolds
Polymer compositions for making fine fibres that can be used as supports for cell culture.
Patent details: Functional polymer fibres for cell-culture scaffolds
- Document title
- Active-ester-group-containing composition for producing fibers, and cell culture scaffold material using fibers produced from active-ester-group-containing composition
- Inventors
- Makiko Umezaki; Takahiro Kishioka; Taito Nishino; Ayako Otani; Kenichiro Kamei; Li Liu; Yong Chen
- Named applicants
- Nissan Chemical; Kyoto University
- Application number(s)
- PCT/JP2015/053890; US: 15/118,481; Japan: 2015-562868
- Earliest priority
- International filing
- Publication dates
- US10240122B2:
JP6504508B2:
WO2015122478A1: - Original document
- Read the published patent PDF ↗
Grant document(s) available
Screening nanofibre environments for cells
Scaffold materials and microfluidic methods for comparing how cells respond to different nanofibre culture environments.
Patent details: Screening nanofibre environments for cells
- Document title
- Cell culture scaffold substrate, microfluidic device, and high-throughput nanofiber screening method using the same
- Inventors
- K. Kamei; Y. Mashimo; L. Liu; Y. Chen
- Named applicants
- Kyoto University
- Application number(s)
- Japan: 2013-263585
- Earliest priority
- Japanese filing
- Publication dates
- JP6433119B2:
- Original document
- Read the published patent PDF ↗
Grant document(s) available
Fibre-on-fibre supports for growing cells in three dimensions
Fine biological fibres placed on a supporting material to provide a three-dimensional environment for cell culture and preservation.
Patent details: Fibre-on-fibre supports for growing cells in three dimensions
- Document title
- Method for three-dimensional culture of cells using fiber-on-fiber and substrate therefor
- Inventors
- K. Kamei; N. Nakatsuji; L. Liu
- Named applicants
- Kyoto University
- Application number(s)
- PCT/JP2014/064789; Japanese national application: 2015-521463
- Earliest priority
- International filing
- Publication dates
- JP6452249B2:
WO2014196549A1: - Original document
- Read the published patent PDF ↗
Dates follow the public documents: priority 2013-06-03, international filing 2014-06-03, international publication 2014-12-11.
Grant document(s) available
Culture substrates for pluripotent stem cells
Substrate designs and culture methods for supporting pluripotent stem cells in the laboratory.
Patent details: Culture substrates for pluripotent stem cells
- Document title
- Method for culturing pluripotent stem cells and substrate therefor
- Inventors
- Yong Chen; Kenichiro Kamei; Li Liu
- Named applicants
- Kyoto University
- Application number(s)
- Japan: 2012-127580
- Earliest priority
- Japanese filing
- Publication dates
- JP6024047B2:
- Original document
- Read the published patent PDF ↗
Earlier work
Microfluidic culture and imaging research at UCLA.
Published application
Microfluidic imaging cytometry
A chip-based system that combines cell-culture chambers, automated liquid handling, and imaging to study many cell samples.
Patent details: Microfluidic imaging cytometry
- Document title
- Microfluidic imaging cytometry
- Inventors
- Hsian-Rong Tseng; Kenichiro Kamei; Jing Sun; Paul S. Mischel; Michael D. Masterman-Smith; David A. Nathanson; Tiffany Huang; Michael van Dam; Christian Behrenbruch; Shawn M. Sarkaria
- Named applicants
- The Regents of the University of California
- Application number(s)
- PCT/US2009/032880
- Earliest priority
- International filing
- Publication dates
- WO2009100028A1:
- Original document
- Read the published patent PDF ↗
The applicant name is taken from the original international patent-document cover.
Published application
Microfluidic platforms for cell culture and assays
Integrated chip-based culture chambers, valves, and fluid control for carrying out cell-culture experiments and biological assays.
Patent details: Microfluidic platforms for cell culture and assays
- Document title
- Microfluidic platform for cell culture and assay
- Inventors
- Hsian-Rong Tseng; Tak For Yu; Shuling Guo; Owen N. Witte; Caius Radu; Jenny Shu; Kenichiro Kamei
- Named applicants
- The Regents of the University of California
- Application number(s)
- United States: 12/520,376
- Earliest priority
- Application filing
- Publication dates
- US20110129850A1:
- Original document
- Read the published patent PDF ↗
An earlier research contribution at UCLA. The publication link identifies the US application document, not a granted US patent.
Invention disclosure
A separately identified earlier disclosure, not a verified published patent.
Earlier invention disclosure
Multiparameter and single-cell signalling analysis
An earlier invention disclosure concerning a bioinformatics approach to measurements of cellular signalling.
UCLA Case No. 2011-887 · Public patent number not verified
Disclosure details: Multiparameter and single-cell signalling analysis
- Disclosure title
- Bioinformatic approach for multiparameter and single-cell signaling measurements
- Contributors
- T. G. Graeber; N. A. Graham; H. R. Tseng; K. Kamei
- Institution
- University of California, Los Angeles (institution listed in the research record)
- Recorded date
- Source
- Kyoto University faculty research record
Retained from the earlier lab website and corroborated by Kyoto University's faculty record. No public patent-publication number was independently matched; this item is not labelled as a granted or published patent.