Nanomedicine · Biological barriers · Disease models
Nano drug delivery
A medicine must reach the right place to work. We investigate tiny delivery systems—and better models for testing how they behave in biological environments.
Why it matters
A promising drug molecule can still fail if too little reaches its target or too much affects healthy tissue. Nanoscale carriers offer ways to protect a payload and influence where or when it is released. But designing a particle is only the start: blood-vessel barriers, surrounding tissue, and cell behavior all affect delivery. Our work links nanomaterial design with tissue-on-a-chip models to investigate these problems.
How we study it
- Design delivery and releaseExplore carriers and prodrugs that respond to chemical conditions. A prodrug is a modified drug designed to become active after a chemical change.
- Test the biological journeyUse tumor-on-a-chip models to examine interactions that a simple flat culture may miss, including barriers and changes in cancer-cell behavior.
- Evaluate evidence beyond a single resultCompare transport, cell response, and potential harm. Reviews of brain delivery also ask whether a system can be manufactured reproducibly and tested in appropriate human-relevant models.
Published examples
Synthetic Polymer Based Nano Drug Delivery Systems for Precise Alzheimer's Disease Therapy
This class-linked review examines polymer carriers, the blood–brain barrier, and trade-offs between delivery, safety, and manufacturability. It evaluates research strategies; it does not announce an approved treatment for Alzheimer's disease.
Nanoengineered Redox-Responsive Platforms for Dual-Targeted NSCLC Therapy with Tumor-on-a-Chip Epithelial-Mesenchymal Transition Profiling
A responsive nanoparticle system combined two therapeutic components and was investigated using a lung-cancer-related tumor-chip model. The work connects delivery design with the study of cell changes associated with drug resistance; clinical benefit is not established by these experiments.
Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system
A review of how tumor chips can be used to investigate nanoparticle transport, tissue barriers, uptake, and treatment response. It also discusses the limitations of the models used to evaluate nanomedicines.