Exciting News! Our latest work in Carbon presents a stimulus-responsive, carrier-free prodrug nano-delivery system for enhanced cancer therapy. By designing ROS-responsive SN38-CA@FC nanoparticles, we achieve a synergistic effect of chemotherapy and ferroptosis, leveraging tumor-specific smart drug release. This approach not only enhances SN38’s therapeutic efficacy but also disrupts redox homeostasis, creating a self-reinforcing ROS feedback loop for amplified anticancer effects. Our in vitro and in vivo results demonstrate significant antitumor activity, highlighting a promising strategy for next-generation cancer treatments.
Title: Self-amplifying ROS-responsive SN38 prodrug nanoparticles for combined chemotherapy and ferroptosis in cancer treatment
Authors: Yu Qin, Na Liu, Fenghui Wang, Zeping Gao, Cong Luo,* Chutong Tian* and Ken-ichiro Kamei*
Publications
Reverse Bioengineering of the Liver: A Development-First Roadmap
A new Perspective proposes liver development as the engineering blueprint for next-generation liver-on-a-chip systems, connecting stem cells, organoids, microfluidics, and Digital Twins.
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