Research

Our latest paper, “Primed human pluripotent stem cell-derived blastocyst-like cell aggregates with partial lineage specification,” has been published in Regenerative Therapy (Elsevier, 2025) — DOI: 10.1016/j.reth.2025.10.007. We report a hydrogel-based method to generate blastocyst-like structures directly from primed human pluripotent stem cells, without the need for naïve reprogramming.These aggregates mimic Read more…

Our latest research has been published in Chemical Engineering Journal: Title: Nanoengineered Redox-Responsive Platforms for Dual-Targeted NSCLC Therapy with Tumor-on-a-Chip Epithelial-Mesenchymal Transition Profiling In this work, we present a rationally designed binary hybrid nanoassembly (OL@R NPs) that co-delivers a redox-responsive platinum(IV) prodrug of oxaliplatin and the ferroptosis inducer RSL3. This Read more…

We are thrilled to share our latest research in collaboration with Shenyang Pharmaceutical University! Our study, led by Dr. Chutong Tian, introduces a self-motivated carrier-free nanoplatform that synergizes photodynamic therapy (PDT) and ferroptosis for targeted anticancer treatment. Title: A self-motivated carrier free nanoplatform for synergistic photodynamic and ferroptosis-based therapy for Read more…

Exciting News! Our latest work in Carbon presents a stimulus-responsive, carrier-free prodrug nano-delivery system for enhanced cancer therapy. By designing ROS-responsive SN38-CA@FC nanoparticles, we achieve a synergistic effect of chemotherapy and ferroptosis, leveraging tumor-specific smart drug release. This approach not only enhances SN38’s therapeutic efficacy but also disrupts redox homeostasis, Read more…

Our recent achievement got published in Frontiers in Bioeng. Biotechnol. Congratulations to Yoshimoto-kun, Nicolas, Kaylene and Janmesh! Thank you very much for Hirai-sensei and Jiandong for your kind contribution! Title: Recapitulation of Human Embryonic Heartbeat to Promote Differentiation of Hepatic Endoderm to Hepatoblasts Journal: Frontiers in Bioeng. Biotechnol. Authors: K. Read more…

Our video protocol has been published in JoVE online. This experiment was based on our publication published in Small, 2017. Please take a look for the video to carry out our experiments! ABSTRACT Cellular microenvironments consist of a variety of cues, such as growth factors, extracellular matrices, and intercellular interactions. These Read more…

Our collaborative achievement with Prof. Inoue-Murayama and Mr. Endo (WRC, Kyoto Univ.) got published in Journal of Evolutionary Biology. “Publications” page in our web was also updated accordingly. Title: Genetic signatures of lipid metabolism evolution in Cetacea since the divergence from terrestrial ancestor Abstract: In mammalian evolutionary history, Cetacea (whales, Read more…