[New Publication] Primed human pluripotent stem cell-derived blastocyst-like cell aggregates with partial lineage specification

Our latest paper, “Primed human pluripotent stem cell-derived blastocyst-like cell aggregates with partial lineage specification,” has been published in Regenerative Therapy (Elsevier, 2025) — DOI: 10.1016/j.reth.2025.10.007.

We report a hydrogel-based method to generate blastocyst-like structures directly from primed human pluripotent stem cells, without the need for naïve reprogramming.
These aggregates mimic key features of early human embryos — including cyst formation, lineage marker organization (epiblast, trophectoderm, and primitive endoderm), and in vitro implantation potential.

This platform provides a more accessible and ethically guided approach for studying human embryogenesis, implantation biology, and early disease modeling.

Congratulations to Kaori and all collaborators at Kyoto University and NYUAD!