Living models · Reverse Bioengineering
Stem cells and regenerative medicine
We design the environments around human pluripotent stem cells to guide fate, organization, and function—from early developmental models to liver and vascular tissues.
Research directions
Programming cell behavior through environment
Programmable environments
Microfluidics, biomaterials, and nanofiber matrices provide controlled biochemical and physical signals.
Early-development models
Stem-cell-based embryo models help us examine selected features of early human development.
Vascular building blocks
High-purity endothelial cells and organized vascular structures support tissue engineering and disease modeling.
Scientific care
Careful models, careful language
Our blastocyst-like cell aggregates display partial lineage specification. We do not equate these systems with natural embryos or claim complete developmental potential.
What we control and measure
Connecting cell fate with engineered environments
Defined extracellular matrices
We vary matrix identity and presentation to study how integrin-mediated signals guide lineage commitment. Sequential matrix switching can reduce heterogeneity and improve endothelial differentiation.
Biochemical timing
Growth-factor and signaling conditions are controlled over time to move cells through pluripotent, progenitor, and specialized states.
Lineage specification
Immunostaining, gene-expression analysis, and single-cell approaches help determine which lineages emerge and how consistently they are organized.
Mechanical environment
Flow, cyclic strain, and fibrous matrices allow us to examine how physical cues influence vascular and liver-bud development.
Regenerative direction
From stem cells toward tissue function
By integrating differentiation with engineered matrices and perfusable culture, we seek reproducible liver, vascular, and multicellular systems for discovery and regenerative medicine.
Selected studies
From early development to vascular tissues
Work with us
Build better environments for living cells.
We welcome researchers and partners interested in differentiation, developmental models, biomaterials, and regenerative medicine.
Contact the lab →