Molecular control · Reverse Bioengineering
Nanoengineering and therapeutic delivery
We design responsive nanoscale materials, control where and when therapeutic signals are released, and evaluate their behavior in human-relevant tumor microenvironments.
Research workflow
Engineer → Deliver → Evaluate
Engineer
Create nanoparticles and fibrous matrices with defined size, chemistry, and response mechanisms.
Deliver
Control therapeutic cargo release and targeting across biological barriers.
Evaluate
Test transport, efficacy, and cell response in tumor-on-chip models.
Human-relevant evaluation
Targeting the tumor microenvironment
Tumors are shaped by heterogeneous cells, extracellular matrix, redox conditions, and transport barriers. Our platforms make these features experimentally accessible so nanoparticle behavior can be studied before broader preclinical evaluation.
What we engineer and evaluate
Following a nanotherapy from carrier to response
Carrier design
Particle size, surface chemistry, therapeutic cargo, and stimulus-responsive linkages are selected to tune stability and release.
Tumor targeting
Dual-targeting strategies are designed to increase association with cancer cells while addressing heterogeneity within the tumor microenvironment.
Triggered release
Redox-responsive systems use disease-associated chemical conditions to promote localized cargo release rather than constitutive exposure.
On-chip profiling
Tumor-on-chip models provide spatially organized cell and matrix environments for evaluating penetration, epithelial–mesenchymal state, and treatment response.
Smart delivery systems
Responsive nanoparticle platforms carry therapeutic molecules and release them under disease-associated conditions.
Engineered cell environments
Nanofiber and Fiber-on-Fiber matrices reproduce selected extracellular features for controlled cell–material studies.
Selected work
Nanoengineering connected to biological evaluation
Foundational work
Controlling biological signals in space and time.
Our earlier gas biology studies established approaches for controlling nitric oxide and continue to inform how we design responsive therapeutic systems.
Discuss a collaboration →