Integrated physiology · Reverse Bioengineering
Body-on-a-Chip and digital twins
We combine human pluripotent stem cell-derived tissues, engineered three-dimensional environments, and microfluidics to model selected interactions within human physiology.
How we work
Reconstructing function, one connection at a time
Build
Generate human cell types and organize them in defined three-dimensional environments.
Connect
Use microfluidics to couple tissue compartments and control biochemical communication.
Measure
Collect functional, imaging, and molecular data to understand system-level responses.
Emerging direction
From physical models to computational counterparts
We aim to connect quantitative Body-on-a-Chip data with computational models that help interpret biological responses and generate testable predictions. Digital twins are a developing research direction—not a claim to reproduce the entire human body.
What the platform captures
Functional readouts across tissues
Tissue function
We assess tissue-specific phenotypes such as hepatic metabolism, lipid accumulation, contractile activity, and cellular organization rather than relying on viability alone.
Barrier and transport
Microfluidic compartments allow us to examine epithelial integrity, molecular transport, and how compounds move between tissue modules.
Cross-organ communication
Closed or recirculating flow connects organ compartments so that metabolites and secreted factors from one tissue can influence another.
Dynamic exposure
Controlled flow, cyclic stimulation, and repeated dosing reproduce selected temporal features missing from static culture.
Selected systems
Case studies across organs
Gut–liver axis
Human gut and liver cells were connected in a closed circulation loop. Free-fatty-acid exposure produced early and progressive features of fatty liver disease, including intracellular lipid accumulation.
Stem-cell-derived liver
Three-dimensional culture supported maturation of hepatocyte-like cells derived from human pluripotent stem cells for liver modeling and chemical-safety testing.
Heart–cancer interaction
An integrated heart/cancer system was used to examine antitumor activity alongside treatment-associated effects on cardiac tissue.
Selected publications
Research behind the platform
Collaborate
Connect models, data, and disciplines.
We welcome collaborations in stem cell biology, microphysiological systems, quantitative modeling, and preclinical development.
Contact the lab →