【論文発表】Optics Letters

廣理先生（京大）、坂口先生（京大）、立崎先生（東海大）との共同研究の成果の論文がOptics Lettersに掲載されました！

京大アイセムスのホームページにも紹介されています。

「高強度テラヘルツ光パルス照射によって変化する ヒトiPS細胞内の遺伝子ネットワークの発見　iPS細胞操作技術に新しい「光」を！」

Title: Terahertz pulse-altered gene networks in human induced pluripotent stem cells

Authors: Takehiro Tachizaki, Reiko Sakaguchi, Shiho Terada, Ken-ichiro Kamei, and Hideki Hirori

Abstract: Terahertz (THz) irradiation has been exploited for biomedical applications in the non-invasive manipulation of living cells. Here, we develop an apparatus for studying the effects of THz pulse irradiation on living human induced pluripotent stem cells (hiPSCs). The spot of focused THz pulse covers the entire cell-culture area, where the maximum electric field reaching 0.5 MV/cm. RNA sequencing of global gene-expression analyses reveals that many THz-regulated genes are driven by zinc-finger (ZNF) transcription factors. These results suggest that the local intracellular concentration of metal ions, such as Zn2+, was changed by the effective electrical force of our THz pulse owing to its quasi-unipolar temporal shape.

DOI: 10.1364/OL.402815

Image credit: Mindy Takamiya @ iCeMS, Kyoto University